The first targeted therapy for Cumulative Detail Fatigue

Restoring precision when the details matter most.

Indication: DEMOZUMAB is indicated for the treatment of moderate-to-severe Cumulative Detail Fatigue (CDF) in adults who have experienced inadequate response to conventional attention management strategies, including scheduled breaks and task rotation.
[Product Image Placeholder]
64%
SDR-50 response at Week 12
3.2 hrs
Median increase in time to first missed detail
Monthly dosing

Introducing CLARITY-1

The largest Phase III trial to date in patients with high-volume cognitive load, evaluating DEMOZUMAB in 847 adults with moderate-to-severe CDF.

Primary Endpoint Results

Proportion of participants achieving Sustained Detail Recognition (SDR-50) at Week 12, defined as ≥50% improvement in error detection rate during standardised assessment tasks.

64%
vs 26% placebo (p<0.001)

DEMOZUMAB demonstrated statistically significant superiority vs placebo in restoring detail recognition capacity in patients with documented precision decline.

Explore full efficacy data →

Support your patients now

CDF affects professionals across high-precision roles. Consider DEMOZUMAB for patients experiencing cognitive load challenges.

[Patient Image Placeholder]

Rebecca

Quality Lead, 12 years' experience

Managing increasing review volumes while maintaining accuracy standards. Noticing more missed inconsistencies in late-afternoon sessions.

Explore efficacy in high-volume CDF
[Patient Image Placeholder]

David

Senior Assessor

Experiencing longer review times and reduced confidence after extended assessment sessions. Concerned about maintaining quality.

Explore mechanism of action
[Patient Image Placeholder]

Priya

Recently promoted

Adapting to greater detail responsibility with less processing time. Seeking support for sustained precision during peak workloads.

Explore dosing flexibility

Why DEMOZUMAB?

Proven efficacy. Targeted mechanism. Convenient monthly dosing.

Proven efficacy

64% SDR-50 response at Week 12 in the CLARITY-1 trial, with sustained response through Week 24.

See efficacy data

Targeted mechanism

Selective CFR-1 inhibition addresses the underlying receptor dysregulation, not just symptoms.

Understand MOA

Convenient dosing

Once-monthly subcutaneous injection. Pre-filled pen available for self-administration.

View dosing guide

Ready to learn more?

Access prescribing information, clinical trial data, and patient resources.

View resources